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Thursday 31 October 2013

Montelukast Sodium » All About Drugs

Montelukast Sodium » All About Drugs:

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Montelukast Sodium » All About Drugs

Montelukast Sodium » All About Drugs:

'via Blog this'

Cinacalcet Hydrochloride spectral data

 


IR (KBr) (cm–1): 3447, 2964, 1587, 800, 776. 


MS: m/z = 358.3 [M + H] +.




1H NMR (CDCl3): δ 1.98 (d, J = 6.7 Hz, 3H), 2.2–2.35 (m, 2H), 2.46–2.60 (m, 2H), 2.55–2.85 (m, 2H), 5.10–5.25 (m, 1H), 7.16–7.26 (m, 3H), 7.31–7.33 (d, J = 7.4 Hz 1H), 7.54–7.65 (m, 3H), 7.88–7.97 (m, 3H), 8.23 (d, J = 7.2 Hz,1H). 

  
13C NMR (DMSO-d6): δ 19.99 (CH3), 27.01 (CH2), 31.50 (CH2), 44.65 (CH2), 52.05 (CH), 122.58, 122.69, 122.73, 124.42, 124.74, 124.67, 125.50, 126.10, 126.88, 128.83, 128.89, 129.32, 130.28, 132.39, 133.32, 134.10, 142.25.
 http://pubs.acs.org/doi/full/10.1021/op300164y


........................................................
next set
  IR (KBr): 3427 (broad, –NH–), 2951, 2797, 2750, 2712, 1587, 1450, 1327, 1165, 1128, 1072, 798, 775 cm−1;  

1H NMR (DMSO-d6/TMS) δ 1.67 (d, J = 6.6, 3H, –CH3), 1.99 (quintet, 2H, –CH2), 2.70 (m, 2H, –CH2), 2.93 (m, 2H, –CH2), 5.30 (q, 1H, –CH), 7.46–7.61 (m, 7H, ArH), 7.95–8.03 (m, 3H, ArH), 8.23 (d, J = 8.0, 1H, ArH), 9.36 (s, 1H, –NH) and 10.04 (s, 1H, HCl); 

 13C NMR (DMSO-d6/TMS) δ 142.61, 134.48, 133.70, 132.80, 130.64, 129.74, 129.58,129.28, 127.29, 126.54, 125.90, 125.08, 124.67, 123.16, 122.98, 52.37, 45.04, 31.84, 27.44, 20.30; 

MS m/z: 358 [M + 1]+.
http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-8-158

...........................
 IR (KBr) cm−1: 3436, 2962, 2797, 1587, 1450, 1379, 1327, 1166, 1129, 797, 774, 746; 
MS: m/z = 358.79 [M + H] +;  
1H NMR (400 MHz, DMSO-d6): δ = 1.67−1.69 (d, 3H), 1.97−2.02 (m, 2H), 2.67−2.69 (t, 4H), 5.27 (q, 1H), 7.44−7.46 (m, 4H), 7.54−7.61 (m, 3H), 7.93−7.99 (m, 2H), 8.026−8.08 (d, J = 7.2 Hz, 1H), 8.20−8.23 (d, J = 7.2 Hz, 1H), 9.46 (s, 1H), 10.17 (s, 1H);  
13C NMR (100 MHz, DMSO-d6): δ = 20.49 (CH3), 27.50 (CH2), 32.02 (CH2), 45.18 (CH2), 52.60 (CH), 123.06, 123..23, 123.26, 124.94, 125.17, 125.21 (CF3), 126.0, 126.60, 127.39, 129.35, 129.39, 129.82, 130.79, 132.88, 133.83, 134.58, 142.75; 
Anal. Calcd for C22H23NF3Cl: C, 67.09; H, 5.84; N, 3.55; Found: C, 66.92; H, 5.68; N, 3.58.
 http://pubs.acs.org/doi/full/10.1021/op200016a

Wednesday 23 October 2013

RABEPRAZOLE SPECTRAL DATA



SPECTRAL DATA FOR RABEPRAZOLE SODIUM
EP 1869015 B1
 IR Spectra (KBr, cm-1): 3382, 2927, 1583, 1462, 1384, 1298, 1269, 1190, 1157, 1093, 1018, 745.

H NMR Spectra [200 M Hz, CD3OD] δ (ppm): 8.23 – 8.25 (1H, d, ArH); 7.57 – 7.62 (2H, m, ArH); 7.0 – 7.09 (2H, m, ArH); 6.87 – 6.90 (1H, d, ArH); 4.57 – 4.63 (2H, d, O=S-CH2-Ar); 4.0 – 4.1 (2H, t, -O-CH2-CH2-); 3.49 – 3.55 (2H, t, -CH2-O-CH3); 3.31 (3H, s, -OCH3); 2.1 (3H, s, Ar-CH3); 1.96 – 2.0 (2H, t, -CH2-CH2-CH2-).
.......................................................

1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.26-8.24 (d, 1H); 7.48-7.44 (m, 2H); 6.92-6.87 (m, 3H); 4.70-4.66 (d, 1H); 4.45-4.41 (d, 1H); 4.09-4.05 (t, 2H); 3.48-3.44 (t, 2H); 3.23 (s, 3H); 2.14 (s, 3H); 1.99-1.93 (q, 2H).
 US 8143409 B2
...........................................................


ONE MORE SOURCE FOR SODIUM RABEPRAZOLE DATA http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf

 IR (KBr, cm-1) 3047 (Ar-H), 2881(Ali-H), 1583 (aromatic
C=C), 1298 (C-N), 1093 (C-O arylalkylether),1027 (S-O,sulphoxide), 745 (Ar-H bending);

MS( ESI)+ve: 382(M++Na);

1H NMR (400MHz, DMSO-d6:
8.44 (d, J=5.6
Hz, 1H), 7.64-7.66 (m, 2H), 7.08-7.10 (m, 3H), 4.60-4.86
(dd, J=13.6, 2H), 4.25 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.4Hz,
2H), 3.40 (s, 3H), 2.31 (s, 3H), 2.13 (qn, J=6.4, 2H).

13CNMR (100 MHz, DMDO-d6) 162.67, 154.68, 150.35,
147.69, 121.40, 119.79, 117.38, 110.49, 106.27, 68.31,
65.09, 57.95, 36.25, 28.68, 10.36.
 .......................................................

 1H NMR (CDCl3
+DMSO) of Rabeprazole sodium (1): δ 2.1 (m, 2H –CH2-), 2.2 (s, 3H, -
CH3), 3.3 (s, 3H, -OCH3), 3.6 (t, 2H, -OCH2-), 4.1 (t, 2H,-CH2-OCH3), 4.5 (d, Ha, -CH2-
pyridine), 4.7 (d, Hb, -CH2-pyridine), 6.6 (d, 1H, 1H-pyridine), 7.1-7.6 (m, 4H, Ar-H),
8.2 (d, 1H, pyridine). http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
.....



 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf  ...........GET IR, NMR GRAPHS FOR RABEPRAZOLE SODIUM HERE

 .....................................................................





......................................................................
SPECTRAL DATA FOR RABEPRAZOLE (WITHOUT SODIUM)

IR (KBr, cm-1) 3064 (Ar-H), 2898(Ali-H), 1581 (aromatic
C=C), 1300 (C-N), 1095 (C-O arylalkylether),1060 (S-O,
sulphoxide), 753 (Ar-H bending);

MS( ESI)+ve: 360(M++1);

1H NMR (400MHz, DMSO-d6: 12.98 (brs, NH),8.28 (d, J=5.6 Hz, 1H), 7.69-7.61 (m, 3H), 6.70 (d, 2H),4.69-4.82 (dd, J=13.6, 2H), 4.05 (t, J=6.4 Hz, 2H), 3.51 (t,J=6.4Hz, 2H), 3.38 (s, 3H), 2.13 (s, 3H), 2.05 (qn, J=6.4,2H).

13C NMR (100 MHz, DMDO-d6)
163.68, 153.14,149.12, 148.22, 122.87, 119.74, 117.40, 110.50, 106.19,
68.74, 65.12, 58.75, 36.27, 29.21, 11.05.



 READ
http://jocpr.com/vol4-iss1-2012/JCPR-2012-4-1-130-139.pdf
 http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
 http://www.ncbi.nlm.nih.gov/pubmed/17945453
 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf
 http://rasayanjournal.co.in/vol-1/issue-1/21.pdf




LATUR, MAHARASHTRA, INDIA

http://en.wikipedia.org/wiki/Latur

Latur
लातूर
Lattalur, Ratnapur
City
Latur is located in Maharashtra
Latur
Latur
Location in Maharashtra, India
Coordinates: 18.40°N 76.56°ECoordinates18.40°N 76.56°E
Country India
StateMaharashtra
RegionAurangabad Division
DistrictLatur
SettledPossibly 7th century AD
Government
 • BodyLatur Municipal Corporation
 • MayorAkhtar Shaikh
Area[1]
 • Total117.78 km2(45.48 sq mi)
Area rank89
Elevation515 m (1,690 ft)
Population (2011)
 • Total382,754
 • Rank89th
 • Density3,200/km2(8,400/sq mi)
DemonymLaturkar
Languages
 • OfficialMarathi
Time zoneIST (UTC+5:30)
PIN
  • 413 512
  • 413 531
Telephone code91-2382
Vehicle registrationMH-24
Sex ratio923.54 /1000 
Literacy89.67
Distance from Mumbai497 kilometres (309 mi) E (land)
Distance fromHyderabad337 kilometres (209 mi) NW (land)
Distance fromAurangabad, Maharashtra294 kilometres (183 mi) SE (land)
ClimateBSh (Köppen)
Precipitation666 millimetres (26.2 in)
Avg. summer temperature41 °C (106 °F)
Avg. winter temperature13 °C (55 °F)
http://www.citypopulation.de/world/Agglomerations.html





















Map of latur city











his Is The Famous 'Ganj-Golai' As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers ...




लातूर जिल्हयातील चित्र संग्रह




LATUR AIRPORT

LATUR AIRPORT













2012 Navratri Mahotsav in Latur





SOS Children's Village Latur











Latur, India: Carnival Resort









Ausa Near Latur







Chakur near Latur



Vilasrao Deshmukh's ancestral home at Babhalgaon village in Latur. Machindra Amle

















UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas ...







The city of Latur is located in India's welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the