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Wednesday 2 April 2014

MK 2048 an HIV integrase inhibitor from Merck


Structure of MK-2048 with important pharmacophore highlighted

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File:MK-2048.svg
MK 2048
Molecular Formula: C21H21ClFN5O4   Molecular Weight: 461.873943


MK 2048
lH NMR (400 MHz, CDCI3) δ 7.48 (dhttp://newdrugapprovals.org/2014/04/02/mk-2048-an-hiv-integrase-inhibitor/d, 7 = 7.0, 2.2 Hz, IH), 7.33 (m, IH), 7.09 (t, 7 = 8.7 Hz, IH), 6.01 (m, IH), 5.33 (d, 7= 14.1 Hz, IH), 5.27 (d, 7 = 14.1 Hz, IH), 3.99 (dd, 7= 12.8, 4.0 Hz, 1 H), 3.71(heptet, 7 = 7.1 Hz, 1 H), 3.49 (heptet, 7 = 7.1 Hz, 1 H), 3.24 (dd, 7 = 13.2, 1.5 Hz, 1 H), 3.03 (d, 7 = 5.1 Hz, 3H), 1.42 (d, 7 = 6.6 Hz, 3H), 1.24 (t, 7 = 7.3 Hz, 3H). 
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