Several gentamicin bulk samples from different origins were investigated using an LC/MS method. LC equipped with ion trap MS with positive ionization was performed on a Capcell Pak C18 (AQ) column with the mobile phase containing 50 mM trif-luoroacetic (TFA) and methanol. Impurities present in batches of gentamicin bulk samples were elucidated and compared ac-cording to their fragmentation behavior. In total seventeen impurities present in samples, five impurities were not elucidated and two compounds were identified preliminarily. It was observed that the impurity profiles were different in samples from different origins which indicate necessity in the quality control of gentamicin.
Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry
ZHENG Chao, WANG BoChu, WANG MingJuan, HOOGMARTENS Jos, SCHEPDAEL Ann Van, ADAMS Erwin
SCIENCE CHINA Chemistry 2011, 54 No. 9
2011 Vol. 54 (9): 1518-1528 [Abstract] ( 306 ) [ PDF (909 KB) ] ( 5767 ) [Supporting Information] DOI: 10.1007/s11426-011-4304-0
http://chem.scichina.com:8081/sciBe/EN/abstract/abstract504534.shtml
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