DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Tuesday 23 December 2014

Protection of Acetol as THP ether

Protection of Acetol as THP ether



 

Protection of Acetol as THP ether

 

Literature References

  1. Xiao, Y.; Liu, P. Angew. Chem. Int. Ed. 2008, 47, 9722-9725.
    • See the supplemental material for a "Synthesis of acetonyl tetrahydropyranyl ether (17)".
  2. Sondheimer, F.; Stjernstrom, N.; Rosenthal, D. J. Org. Chem. 1959, 24, 1280-1284.
    • Look for the experimental for "Acetol 2'-tetrahydropyranyl ether (VIIIb)". Interestingly, they say that the material was stored at -10 degrees C, or used directly for the next step since it decomposed on standing at room temperature!
  3. Hagiwara, H.; Uda, H. J. Chem. Soc., Perkin-I 1984, 91.
  The literature listing for the NMR (Xiao reference above) is 1H-NMR (CDCl3, 400 MHz): 4.64 (t, J = 3.6 Hz, 1 H), 4.26 (d, J = 17.6 Hz, 1 H), 4.12 (d, J = 17.6 Hz, 1 H), 3.81-3.86 (m, 1 H), 3.49-3.54 (m, 1 H), 2.18 (s, 3 H), 1.61-1.89 (m, 6 H).









 DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

View Anthony Melvin Crasto Ph.D's profile on LinkedIn

Join me on Facebook FACEBOOK
Join me on twitterFollow amcrasto on Twitter     
Join me on google plus Googleplus

 amcrasto@gmail.com


No comments:

Post a Comment