DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Thursday 8 January 2015

3,3-Dicarbethoxy-3,4-dihydro-9-(1-methylethylidene)-1,4-methano-1H-2-benzopyran


3,3-Dicarbethoxy-3,4-dihydro-9-(1-methylethylidene)-1,4-methano-1H-2-benzopyran
37
 
3,6-Di(2-pyridyl)­s­tetrazine (0.45g; 1.9 mmol) was added slowly to a stirred solution of the hydrocarbon 33 (0.30g; 1.6 mmol) and diethyl oxomalonate 36(0.25 ml); 1.6 mmol) in chloroform (10 ml) and the resulting solution stirred for 1 hour. Removal of the solvent afforded the crude product. Attempts to purify this product by chromatography on silica gel or alumina only resulted in its rearrangement. However, the p.m.r. spectrum (CDCl3) of the product could be deduced from that of the crude compound: d 1.02 (3H, t J = 7 Hz, endo-OCH2CH3), 1.30 (3H, t J = 7 Hz), exo-OCH2CH3), 1.72 (3H, s, methyl protons), 1.76 (3H, s, methyl protons), 3.96 (2H, q J = 7 Hz, endo-OCH2CH3), 4.36 (2H, q J = 7 Hz, exo-OCH2CH3), 4.74 (1H, d Ja,b = 1.5 Hz, Hb) 5.76 (1H, d Ja,b = 1.5 Hz, Ha), 7.10-7.60 (4H, m, aromatic protons), and the mass spectrum showed the parent ion at m/e 330.










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