DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Monday 30 November 2015

4,4-Dimethoxybut-1-yne

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4,4-Dimethoxybut-1-yne: 1-butyne, 4,4-dimethoxy-; 4,4-Dimethoxy-1-butyne; 4,4-Dimethoxybut-1-yne; (1) (33639-45-1)



4,4-Dimethoxybut-1-yne (1) has the following physical and spectroscopic properties: bp 62-67 °C (75 mmHg);

1H NMR (CDCl3, 600 MHz)
δ 2.03 (t, J = 2.7 Hz, 1 H),TRIPLE BOND H
2.53 (dd, J = 5.6, 2.7 Hz, 2 H), CH2
3.38 (s, 6 H), TWO METHOXY
4.55 (t, J = 5.6 Hz, 1 H).      O-CH-O



  

13C NMR (CDCl3, 150 MHz) δ: 23.7, 53.4, 70.2, 79.3, 102.3.








HRMS (ESI) m/z: Calcd. for C6H10O2 [M+Na]+: 137.0573, found: 137.0573.

IR (cm-1): 3289, 2938, 2834, 2124, 1447, 1423, 1362, 1240, 1192, 1120, 1064.

Anal. calcd for C6H10O2: C, 63.14; H, 8.83. Found: C, 62.86; H, 8.86.






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Sunday 29 November 2015

(S)-tert-Butyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate





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 (S)-tert-Butyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate










Boc-L-proline
Boc-L-Proline: Boc-Pro-OH, N-(tert-Butoxycarbonyl)-L-proline; (15761-39-4)

benzylamine
Benzylamine: α-Aminotoluene; (100-46-9)

IR (neat) 3310, 2976, 2871, 1682, 1652, 1526, 1393, 1370, 1157, 1127, 766, 724, 693 cm-1. mp 124-125 °C.  




1H NMR (600 MHz, d-6 DMSO)

Major rotamer δ: 1.28 (s, 6 H), 1.41 (s, 3 H), 1.67 - 1.90 (m, 3 H), 2.04 - 2.18 (m, 1 H), 3.25 - 3.32 (m, 1 H), 3.36 - 3.43 (m, 1 H), 4.08 (dd, J = 8.6, 3.1 Hz, 1 H), 4.21 (dd, J = 14.0, 5.9 Hz, 1 H), 4.34 (dd, J = 14.0, 5.9 Hz, 1 H), 7.20-7.34 (m, 5 H), 8.39 (t, J = 5.9 Hz, 1 H).

Minor rotamer δ: 1.28 (s, 6 H), 1.41 (s, 3 H), 1.67 - 1.90 (m, 3 H), 2.04 - 2.18 (m, 1H), 3.25 - 3.32 (m, 1 H), 3.36 - 3.43 (m, 1 H), 4.12 (dd, J = 8.6, 3.1 Hz, 1 H), 4.19 (dd, J = 14.0, 5.9 Hz, 1 H), 4.34 (dd, J = 14.0, 5.9 Hz, 1 H), 7.20-7.34 (m, 5 H), 8.34 (t, J = 5.9 Hz, 1 H).  

1H NMR (600 MHz, DMSO, 60 °C) δ: 1.29 (s, 9 H), 1.67 - 1.91 (m, 2 H), 1.99 - 2.20 (m, 1 H), 3.29 (dt, J = 10.5, 6.8 Hz, 1 H), 3.38 (ddd, J = 10.5, 7.5, 5.1 Hz, 1 H), 4.10 (s, 1 H), 4.21 (dd, J = 14.9, 6.0 Hz, 1 H), 4.31 (dd, J = 14.9, 6.0 Hz, 1 H), 7.20 (t, J = 6.8 Hz, 1 H), 7.23 - 7.31 (m, 4 H), 8.16 (s, 1 H).


13C NMR (150 MHz, d-6 DMSO)




Major rotamer δ: 23.6, 28.4, 31.6, 42.5, 47.0, 60.4, 78.9, 127.8, 128.6, 140.1, 153.8, 172.9;

Minor rotamer δ: 24.5, 28.66, 30.5, 42.3, 47.2, 60.3, 79.1, 127.0, 127.19, 127.3, 140.1, 154.2, 172.7.

HRMS m/z calcd for C17H25N2O3 [M + H]+: 305.1860; Found: 305.1856. Anal. calcd for C17H24N2O3: C, 67.08; H, 7.95; N, 9.20; Found: C, 67.02; H, 7.89; N, 9.04.

Chiral HPLC AD-H column, 90:10 isohexane:2-PrOH, flow 0.7 mL/min, 30 °C, retention time 18.54 min (Retention times for racemic sample = 7.16 min and 19.93 min).








 

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In the shadow of the Pyramids: the Nazlet El-Seman district in #Egypt's #Giza.

[Photo by Roger Anis from Everyday Egypt]



 
 
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Where are you spending your morning?



 

 
 
#Sphinx with #Pyramids #Egypt

 


 

 
 
Egypt - Pyramids view from Mena House Hotel rooms, Giza

 
 

 

 

 


 
 
 

 


 






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