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Thursday 30 June 2016

Easy Preparation of Alkyl Amides





Simple method for making amides from alkyl iodides, amines, and a CO source

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SEE

http://www.chemistryviews.org/details/ezine/9444071/Easy_Preparation_of_Alkyl_Amides.html?elq_mid=10462&elq_cid=1558306

A novel, mild and facile preparation of alkyl amides from unactivated alkyl iodides employing a fac-Ir(ppy)3-catalyzed radical aminocarbonylation protocol has been developed. Using a two-chambered system, alkyl iodides, fac-Ir(ppy)3, amines, reductants, and CO gas (released ex situ from Mo(CO)6), were combined and subjected to an initial radical reductive dehalogenation generating alkyl radicals, and a subsequent aminocarbonylation with amines affording a wide range of alkyl amides in moderate to excellent yields.



N-isopropylcyclohexanecarboxamide[2] (1a) (CAS 6335-52-0)
Prepared following the general procedure. Spectral data were in agreement with literature values. White solid (39 mg, 78%), Rf = 0.10 (10% EtOAc in n-pentane).

1H NMR (400 MHz, CDCl3): δ 5.19 (s, 1H), 4.07 (dt, J = 8.0, 6.6 Hz, 1H), 2.00 (tt, J = 11.7, 3.5 Hz, 1H), 1.89–1.72 (m, 4H), 1.74–1.52 (m, 1H), 1.48–1.35 (m, 2H), 1.31–1.18 (m, 3H), 1.13 (d, J = 6.6 Hz, 6H).

13C{1H} NMR (100 MHz, CDCl3): δ 175.4, 45.8, 41.1, 29.9, 25.9, 23.0. EI-MS: m/z 169.2.

2] O. Itsenko, T. Kihlberg, B. Långström, J. Org. Chem. 2004, 69, 4356–4360.




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Tenerife


 Tenerife Island


Sunset at Tenerife Island — in Tenerife.
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Map of Tenerife
Tenerife
Island in Spain
Tenerife, the largest of Spain’s Canary Islands, off West Africa, is dominated by Mt. Teide, which rises 7,500m above the ocean floor and is among the world’s largest volcanoes. Still, Tenerife may be best known for its huge pre-Lent Carnival, as well as its beaches (with sands from yellow to black) and busy, upscale resorts, including Los Cristianos and Playa de las Américas.
 

 

 

 
Candeleria church at tenerife
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Tuesday 28 June 2016

Butyl 1-methylindole-3-carboxylate





Heteronuclear multiple bond coherence (HMBC) spectrum of 3a
 ZINC35973670.png
Butyl 1-methylindole-3-carboxylate
Molecular Formula:

C14H17NO2
Molecular Weight: 231.29028 g/mol










////////////////////////c21ccccc1n(cc2C(=O)OCCCC)C




 Cres, Primorsko-Goranska, Croatia.


 
 

 
 

 

 
 
 
 
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Menthyl 1-methylindole-3-carboxylate




Menthyl 1-methylindole-3-carboxylate
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Portree,  scotland, uk





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